Issue 30, 2014

Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars

Abstract

Although various studies related to nanoparticles-based photothermal therapy have been actively performed, an epoch-making photothermolysis therapy exhibiting both high selectivity and efficiency has yet not been discovered. For the first time, we have developed novel valuable therapeutic complexes, namely, dual aptamer-modified gold nanostars, for the targeting of prostate cancers, including PSMA(+) and PSMA(−) cells. The synthesized probes were characterized through several techniques, including UV-VIS spectral analysis, DLS analysis, zeta potential measurements, and TEM imaging, and were subsequently subjected to cytotoxicity tests, cell uptake confirmation, and in vitro photothermal therapy. The homogeneously well-fabricated nanostars presented high selectivity to prostate cancer cells and extremely high efficiency for therapy using an 808 nm laser under an irradiance of 0.3 W cm−2, which is lower than the permitted value for skin exposure (0.329 W cm−2). It is anticipated that this novel photothermal agent will become the general platform for targeted therapy.

Graphical abstract: Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars

Supplementary files

Article information

Article type
Paper
Submitted
24 Apr 2014
Accepted
04 Jun 2014
First published
04 Jun 2014

J. Mater. Chem. B, 2014,2, 4862-4867

Author version available

Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars

H. Jo, H. Youn, S. Lee and C. Ban, J. Mater. Chem. B, 2014, 2, 4862 DOI: 10.1039/C4TB00643G

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