Issue 35, 2014

Blood compatible materials: state of the art

Abstract

Devices that function in contact with blood are ubiquitous in clinical medicine and biotechnology. These devices include vascular grafts, coronary stents, heart valves, catheters, hemodialysers, heart-lung bypass systems and many others. Blood contact generally leads to thrombosis (among other adverse outcomes), and no material has yet been developed which remains thrombus-free indefinitely and in all situations: extracorporeally, in the venous circulation and in the arterial circulation. In this article knowledge on blood–material interactions and “thromboresistant” materials is reviewed. Current approaches to the development of thromboresistant materials are discussed including surface passivation; incorporation and/or release of anticoagulants, antiplatelet agents and thrombolytic agents; and mimicry of the vascular endothelium.

Graphical abstract: Blood compatible materials: state of the art

Article information

Article type
Feature Article
Submitted
31 May 2014
Accepted
16 Jul 2014
First published
17 Jul 2014

J. Mater. Chem. B, 2014,2, 5718-5738

Blood compatible materials: state of the art

X. Liu, L. Yuan, D. Li, Z. Tang, Y. Wang, G. Chen, H. Chen and J. L. Brash, J. Mater. Chem. B, 2014, 2, 5718 DOI: 10.1039/C4TB00881B

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