Issue 41, 2014

Graphene loading water-soluble phthalocyanine for dual-modality photothermal/photodynamic therapy via a one-step method

Abstract

In this paper, we present a new and facile one-step method for the fabrication of a water-soluble graphene–phthalocyanine (GR–Pc) hybrid material by simply sonicating GR with a hydrophilic Pc, tetrasulfonic acid tetrasodium salt copper phthalocyanine (TSCuPc). In the resultant hybrid material, TSCuPc is coated on the skeleton of pristine GR via non-covalently π–π interaction, detailedly characterized by UV-vis/Raman spectra, X-ray photoelectron spectroscopy (XPS), etc. The obtained GR–Pc hybrid (GR–TSCuPc) is applied for photothermal therapy (PTT) and photodynamic therapy (PDT). In this PTT/PDT system, both GR and TSCuPc operate as multifunctional agents: GR acts as a photosensitizer carrier and PTT agent, while TSCuPc acts as a hydrophilic PDT agent. Furthermore, the results of cell viability show that the phototherapy effect of GR–TSCuPc is observably higher than that of free TSCuPc, indicating that combined noninvasive PTT/PDT exhibits better anti-cancer efficacy in vitro. Such results highlight that this work provide a facile method to develop efficacious dual-modality carbon nanoplatform for developing cancer therapeutics.

Graphical abstract: Graphene loading water-soluble phthalocyanine for dual-modality photothermal/photodynamic therapy via a one-step method

Supplementary files

Article information

Article type
Paper
Submitted
26 Jun 2014
Accepted
19 Aug 2014
First published
21 Aug 2014

J. Mater. Chem. B, 2014,2, 7141-7148

Author version available

Graphene loading water-soluble phthalocyanine for dual-modality photothermal/photodynamic therapy via a one-step method

B. Jiang, L. Hu, D. Wang, S. Ji, X. Shen and H. Liang, J. Mater. Chem. B, 2014, 2, 7141 DOI: 10.1039/C4TB01038H

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