Issue 13, 2015

An anionic conjugated polymer as a multi-action sensor for the sensitive detection of Cu2+ and PPi, real-time ALP assaying and cell imaging

Abstract

A Cu2+ ensemble polyfluorene derivative, poly[5,5′-(((9H-fluorene-9,9-diyl)bis(hexane-6,1-diyl))bis(oxy))diisophthalate] sodium salt (PFT), displays unprecedented selectivity for PPi (LOD = 2.26 ppb) in aqueous solution as well as in random urine samples at physiological pH vis-a-vis monitoring ALP activity. Furthermore, intracellular imaging of Cu2+ and PPi in mouse macrophage (J774A.1) and human breast cancer cells (MDA-MB231) was achieved to confirm the viability of PFT in biological systems.

Graphical abstract: An anionic conjugated polymer as a multi-action sensor for the sensitive detection of Cu2+ and PPi, real-time ALP assaying and cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
06 May 2015
Accepted
14 May 2015
First published
14 May 2015

Analyst, 2015,140, 4388-4392

An anionic conjugated polymer as a multi-action sensor for the sensitive detection of Cu2+ and PPi, real-time ALP assaying and cell imaging

A. H. Malik, S. Hussain, A. S. Tanwar, S. Layek, V. Trivedi and P. K. Iyer, Analyst, 2015, 140, 4388 DOI: 10.1039/C5AN00905G

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