Issue 17, 2015

Old is new again: a chemical probe for targeting mitochondria and monitoring mitochondrial membrane potential in cells

Abstract

Here, we explore the new application of an old molecule. We find that the tetraphenylethene-indolium molecule (TPE-indo) can both image the mitochondria (in the aggregated state), and indicate mitochondrial activity by the fluorescence change of TPE-indo. TPE-indo shows good photostability, longer emission wavelength, targeting effect for mitochondria, and better response to the changes of the mitochondrial membrane potential (ΔΨm).

Graphical abstract: Old is new again: a chemical probe for targeting mitochondria and monitoring mitochondrial membrane potential in cells

Supplementary files

Article information

Article type
Communication
Submitted
07 May 2015
Accepted
19 Jun 2015
First published
19 Jun 2015

Analyst, 2015,140, 5849-5854

Author version available

Old is new again: a chemical probe for targeting mitochondria and monitoring mitochondrial membrane potential in cells

L. Zhang, W. Liu, X. Huang, G. Zhang, X. Wang, Z. Wang, D. Zhang and X. Jiang, Analyst, 2015, 140, 5849 DOI: 10.1039/C5AN00918A

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