Issue 9, 2016

Core–shell Fructus Broussonetia-like Au@Ag@Pt nanoparticles as highly efficient peroxidase mimetics for supersensitive resonance-enhanced Raman sensing

Abstract

We herein present a simple and surfactant-free synthetic strategy for the preparation of core–shell Fructus Broussonetia-like Au@Ag@Pt nanoparticles (FBNPs) via a combination of galvanic replacement and reagent reduction, in which a chitosan (CS)-mediated epitaxial growth of Pt multi-branches occurs on cresyl violet labeled Au core–Ag shell nanoparticles (NPs) at room temperature. The as-prepared novel nanostructures exhibit an enzyme mimetic activity due to the formation of a Fructus Broussonetia-shaped Pt shell, the absence of surfactants and the positively charged CS molecules intertwined within the outermost Pt NPs. Relying on the high sensitivity of resonance-enhanced Raman scattering and the highly efficient intrinsic peroxidase-like activity of FBNPs, H2O2 was detected with a wide detection window from 10 pM to 100 μM when utilizing 3,3′,5,5′-tetramethylbenzidine (TMB) as the substrate. Based on the H2O2–TMB catalytic oxidation system a simple, sensitive, selective and universal platform has been extended for the detection of all peroxidase-related analytes. For example, glucose at a concentration range of 1 nM to 200 μM was detected in the presence of glucose oxidase with a limit of detection of 1 nM.

Graphical abstract: Core–shell Fructus Broussonetia-like Au@Ag@Pt nanoparticles as highly efficient peroxidase mimetics for supersensitive resonance-enhanced Raman sensing

Supplementary files

Article information

Article type
Paper
Submitted
30 Nov 2015
Accepted
03 Feb 2016
First published
04 Feb 2016

Anal. Methods, 2016,8, 2097-2105

Author version available

Core–shell Fructus Broussonetia-like Au@Ag@Pt nanoparticles as highly efficient peroxidase mimetics for supersensitive resonance-enhanced Raman sensing

J. Li, L. Lv, G. Zhang, X. Zhou, A. Shen and J. Hu, Anal. Methods, 2016, 8, 2097 DOI: 10.1039/C5AY03124A

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