Issue 3, 2016

PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin

Abstract

Redox-responsive polymers exhibit great potential as drug delivery systems. Herein, a redox-responsive PEGylated hyperbranched polyphosphoester (PPE) was synthesized through (A2 + B3) type polycondensation. The obtained hyperbranched PPE can self-assemble into nanoparticles in water. The biocompatibility of the nanoparticles was evaluated. The hydrophobic chemotherapy drug doxorubicin (DOX) can be efficiently encapsulated into the obtained nanoparticles. Such DOX-loaded nanoparticles exhibited excellent stability due to the PEGylation, and showed redox-responsive drug release behavior. In addition, flow cytometric analyses demonstrated that the redox-responsive nanoparticles could be efficiently internalized into the human breast cancer cell line MDA-MB-231, and intracellular glutathione enhanced the intracellular drug release from the redox-responsive hyperbranched PPE based nanoparticles. Therefore, such nanoparticles resulted in the enhanced inhibition of tumor cell growth, suggesting the potential of redox-responsive PEGylated hyperbranched PPE in anticancer drug delivery.

Graphical abstract: PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin

Article information

Article type
Paper
Submitted
08 Oct 2015
Accepted
12 Nov 2015
First published
02 Dec 2015

Biomater. Sci., 2016,4, 412-417

PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin

C. Chen, P. Zheng, Z. Cao, Y. Ma, J. Li, H. Qian, W. Tao and X. Yang, Biomater. Sci., 2016, 4, 412 DOI: 10.1039/C5BM00440C

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