Issue 4, 2016

Nano-formulation of a photosensitizer using a DNA tetrahedron and its potential for in vivo photodynamic therapy

Abstract

Photodynamic therapy (PDT) is a cytotoxic treatment using singlet oxygen produced by photosensitizers. Approved porphyrinoid PDT still suffers from a lack of robust production methods and low water solubility. Methylene blue (MB) is a good candidate for the PDT drug, because the dye is an effective photosensitizer, can be easily synthesized, and is already being used in other clinical fields. However, its poor cell/tissue penetration and low stability against the reducible biological conditions should be addressed by using a proper delivery vehicle. Here, we employed a DNA tetrahedron, a self-assembled nanostructure as the carrier for intracellular delivery of MB by taking advantage of the DNA binding property of the photosensitizer and demonstrated photo-induced cytotoxicity by the MB delivered by the DNA nanocarrier. We also evaluated the PDT potency of the MB-loaded DNA nanoconstruct in vivo tumor model to suppress tumor growth.

Graphical abstract: Nano-formulation of a photosensitizer using a DNA tetrahedron and its potential for in vivo photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
19 Oct 2015
Accepted
03 Dec 2015
First published
17 Dec 2015

Biomater. Sci., 2016,4, 605-609

Nano-formulation of a photosensitizer using a DNA tetrahedron and its potential for in vivo photodynamic therapy

K. Kim, D. Bang and D. Ahn, Biomater. Sci., 2016, 4, 605 DOI: 10.1039/C5BM00467E

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