Issue 21, 2015
From the journal:

Chemical Communications

Palladium(ii)-catalysed ortho-arylation of N-benzylpiperidines†

Peng Wen Tan,a   Maxwell Haugheya  and  Darren J. Dixon*a  

* Corresponding authors

a Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK
E-mail: darren.dixon@chem.ox.ac.uk

Abstract

PdII-catalysed ortho-arylation of benzylic heterocycles with arylboronic acid pinacol esters (Ar-BPin) via directed C–H bond activation to generate the desired biaryl products is reported. This methodology is efficient and applicable to a wide range of functionalised Ar-BPin and benzylic heterocycles, allowing the direct synthesis of important biaryl motifs in modest to good yield.

Graphical abstract: Palladium(ii)-catalysed ortho-arylation of N-benzylpiperidines

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Article information

DOI
https://doi.org/10.1039/C5CC00410A
Article type
Communication
Submitted
15 Jan 2015
Accepted
05 Feb 2015
First published
05 Feb 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 4406-4409

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Palladium(II)-catalysed ortho-arylation of N-benzylpiperidines

P. W. Tan, M. Haughey and D. J. Dixon, Chem. Commun., 2015, 51, 4406 DOI: 10.1039/C5CC00410A

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