Issue 32, 2015

General CuBr2-catalyzed highly enantioselective approach for optically active allenols from terminal alkynols

Abstract

Here, we show a CuBr2-catalyzed approach for a highly enantioselective synthesis (93–99% ee) of allenols from aldehydes and terminal alkynols with the absolute configuration being controlled by applying readily available (R)- or (S)-α,α-diphenylprolinol.

Graphical abstract: General CuBr2-catalyzed highly enantioselective approach for optically active allenols from terminal alkynols

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2015
Accepted
05 Mar 2015
First published
06 Mar 2015

Chem. Commun., 2015,51, 6956-6959

General CuBr2-catalyzed highly enantioselective approach for optically active allenols from terminal alkynols

X. Huang, T. Cao, Y. Han, X. Jiang, W. Lin, J. Zhang and S. Ma, Chem. Commun., 2015, 51, 6956 DOI: 10.1039/C5CC00697J

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