Cp2TiCl2-catalyzed cis-hydroalumination of propargylic amines with Red-Al: stereoselective synthesis of Z-configured allylic amines

Renhong Sun; Jun Liu; Shuang Yang; Ming Chen; Ning Sun; Haoyi Chen; Xin Xie; Xu You; Shi Li; Yuanhong Liu

doi:10.1039/C5CC00950B

Cp₂TiCl₂-catalyzed cis-hydroalumination of propargylic amines with Red-Al: stereoselective synthesis of Z-configured allylic amines†

Renhong Sun,^a Jun Liu,^a Shuang Yang,^a Ming Chen,^a Ning Sun,^a Haoyi Chen,^a Xin Xie,^a Xu You,^a Shi Li^a and Yuanhong Liu*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China
E-mail: yhliu@sioc.ac.cn

Abstract

A titanium-catalyzed cis-hydroalumination of propargylic amines with Red-Al is described, which provides an efficient way to produce Z-configured allylic amines in good to excellent yields with high stereoselectivity and good regioselectivity. The hydride-bridged Al/Ti bimetallic species may act as a real catalyst in this reaction.

Chemical Communications

Cp₂TiCl₂-catalyzed cis-hydroalumination of propargylic amines with Red-Al: stereoselective synthesis of Z-configured allylic amines†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Permissions

Cp₂TiCl₂-catalyzed cis-hydroalumination of propargylic amines with Red-Al: stereoselective synthesis of Z-configured allylic amines

Social activity

Search articles by author

Spotlight

Advertisements

Chemical Communications