Issue 23, 2015
From the journal:

Chemical Communications

DNA–ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade†

Daria V. Berdnikova,*ab   Tseimur M. Aliyeu,b   Thomas Paululat,a   Yuri V. Fedorov,b   Olga A. Fedorovab  and  Heiko Ihmelsa  

* Corresponding authors

a Department Chemie–Biologie, Organische Chemie II, Universität Siegen, Adolf-Reichwein-Str. 2, 57068 Siegen, Germany
E-mail: berdnikova@chemie-bio.uni-siegen.de, daria@ineos.ac.ru

b A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova str. 28, 119991 Moscow, Russia

Abstract

A supramolecular five-component cascade is presented that enables light-controlled transport of an in situ modified ligand between three host systems based on the different complexation preferences of cyclodextrin, cucurbituril, and double-stranded DNA. The results point out novel approaches for the control of drug–DNA interactions in DNA-targeting therapy.

Graphical abstract: DNA–ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade

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Article information

DOI
https://doi.org/10.1039/C5CC01025J
Article type
Communication
Submitted
03 Feb 2015
Accepted
14 Feb 2015
First published
16 Feb 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 4906-4909

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DNA–ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade

D. V. Berdnikova, T. M. Aliyeu, T. Paululat, Y. V. Fedorov, O. A. Fedorova and H. Ihmels, Chem. Commun., 2015, 51, 4906 DOI: 10.1039/C5CC01025J

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