Issue 29, 2015
From the journal:

Chemical Communications

A reusable microRNA sensor based on the electrocatalytic property of heteroduplex-templated copper nanoclusters†

Zhaoyin Wang,a   Ling Si,a   Jianchun Baoa  and  Zhihui Dai*a  

* Corresponding authors

a Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials and Jiangsu key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China
E-mail: daizhihuii@ninu.edu.cn
Fax: +86-25-85891051
Tel: +86-25-85891051

Abstract

DNA–RNA heteroduplexes have been used as templates for copper nanocluster (CuNC) formation for the first time. Taking advantage of the electrocatalysis of CuNCs, quantitation of miRNA can thus be accomplished. More importantly, by simply operating several rounds of CuNC formation, repeated detection of miRNA has further been realized, which is rare in miRNA biosensors.

Graphical abstract: A reusable microRNA sensor based on the electrocatalytic property of heteroduplex-templated copper nanoclusters

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Article information

DOI
https://doi.org/10.1039/C5CC01081K
Article type
Communication
Submitted
05 Feb 2015
Accepted
04 Mar 2015
First published
11 Mar 2015

Chem. Commun., 2015,51, 6305-6307

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A reusable microRNA sensor based on the electrocatalytic property of heteroduplex-templated copper nanoclusters

Z. Wang, L. Si, J. Bao and Z. Dai, Chem. Commun., 2015, 51, 6305 DOI: 10.1039/C5CC01081K

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