Issue 31, 2015
From the journal:

Chemical Communications

GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release†

Xuan Wu,a   Yan Li,b   Chen Lin,a   Xiao-Yu Hu*a  and  Leyong Wang*a  

* Corresponding authors

a Key Laboratory of Mesoscopic Chemistry of MOE, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
E-mail: lywang@nju.edu.cn
Fax: +86 25 83597090
Tel: +86 25 83592529

b State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China

Abstract

Novel GSH- and pH-responsive supramolecular vesicles constructed by an amphiphilic inclusion complex formed from water-soluble pillar[5]arene and lysine derivative have been successfully developed, which can efficiently encapsulate anticancer drug MTZ and show rapid MTZ-release in a simulated acidic tumor environment with high GSH concentration, and exhibit potent antitumor activity.

Graphical abstract: GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release

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Article information

DOI
https://doi.org/10.1039/C5CC01393C
Article type
Communication
Submitted
14 Feb 2015
Accepted
09 Mar 2015
First published
11 Mar 2015

Chem. Commun., 2015,51, 6832-6835

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GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release

X. Wu, Y. Li, C. Lin, X. Hu and L. Wang, Chem. Commun., 2015, 51, 6832 DOI: 10.1039/C5CC01393C

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