Issue 38, 2015
From the journal:

Chemical Communications

Oxidative N-heterocyclic carbene catalyzed stereoselective annulation of simple aldehydes and 5-alkenyl thiazolones†

Li Lin,‡*a   Yuhong Yang,‡a   Mei Wang,a   Luhao Lai,a   Yarong Guoa  and  Rui Wang*ab  

* Corresponding authors

a Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
E-mail: linli@lzu.edu.cn, wangrui@lzu.edu.cn
Fax: +86 0931-8912567

b State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

Abstract

A highly diastereoselective annulation of simple aldehydes and 5-alkenyl thiazolones, via oxidative NHC catalysis has been developed. This strategy provides facile access to a diverse library of functionalized chiral thiazolo pyrones. Aerobic oxygen can also be applied as a secondary oxidant to avoid the use of stoichiometric organic or inorganic oxidants.

Graphical abstract: Oxidative N-heterocyclic carbene catalyzed stereoselective annulation of simple aldehydes and 5-alkenyl thiazolones

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Article information

DOI
https://doi.org/10.1039/C5CC01587A
Article type
Communication
Submitted
25 Feb 2015
Accepted
23 Mar 2015
First published
23 Mar 2015

Chem. Commun., 2015,51, 8134-8137

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Oxidative N-heterocyclic carbene catalyzed stereoselective annulation of simple aldehydes and 5-alkenyl thiazolones

L. Lin, Y. Yang, M. Wang, L. Lai, Y. Guo and R. Wang, Chem. Commun., 2015, 51, 8134 DOI: 10.1039/C5CC01587A

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