Issue 51, 2015

Metabolic remodeling of bacterial surfaces via tetrazine ligations

Abstract

Bioorthogonal click ligations are extensively used for the introduction of functional groups in biological systems. Tetrazine ligations are attractive in that they are catalyst-free and display favorable kinetics. We describe the efficient remodeling of bacterial cell surfaces using unnatural D-amino acids derivatized with tetrazine ligation handles. The metabolic incorporation of these unnatural D-amino acids onto bacterial cell surfaces resulted in a site-selective installation of fluorophores.

Graphical abstract: Metabolic remodeling of bacterial surfaces via tetrazine ligations

Supplementary files

Article information

Article type
Communication
Submitted
25 Feb 2015
Accepted
22 May 2015
First published
22 May 2015

Chem. Commun., 2015,51, 10330-10333

Author version available

Metabolic remodeling of bacterial surfaces via tetrazine ligations

S. E. Pidgeon and M. M. Pires, Chem. Commun., 2015, 51, 10330 DOI: 10.1039/C5CC01693B

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