Issue 47, 2015

Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines

Abstract

α-2,9-Di-, tri-, tetra-, and pentasialic acids were prepared and conjugated with a carrier protein. The resultant glycoconjugates elicited robust T cell-mediated immunity in mice. α-2,9-Trisialic acid was identified as a promising antigen for developing glycoconjugate vaccines against group C Neisseria meningitidis.

Graphical abstract: Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines

Supplementary files

Article information

Article type
Communication
Submitted
02 Mar 2015
Accepted
28 Apr 2015
First published
28 Apr 2015

Chem. Commun., 2015,51, 9647-9650

Author version available

Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines

G. Liao, Z. Zhou and Z. Guo, Chem. Commun., 2015, 51, 9647 DOI: 10.1039/C5CC01794G

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