Issue 39, 2015
From the journal:

Chemical Communications

Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans†

Youqiang Lin,a   Limin Yang,*a   Yue Denga  and  Guofu Zhong*a  

* Corresponding authors

a College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310018, China
E-mail: myang@hznu.edu.cn, zgf@hznu.edu.cn

Abstract

A chiral cooperative catalysis of NHC and Brønsted acid for a formal [4+2] reaction of unprotected isatins and enals was developed for the direct synthesis of unprotected spiro[indoline-3,2′-pyran]-2,6′(3′H)-diones in good to excellent yields (up to 95%) with high enantioselectivities (up to >93% ee).

Graphical abstract: Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans

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Article information

DOI
https://doi.org/10.1039/C5CC02096D
Article type
Communication
Submitted
11 Mar 2015
Accepted
05 Apr 2015
First published
08 Apr 2015

Chem. Commun., 2015,51, 8330-8333

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Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans

Y. Lin, L. Yang, Y. Deng and G. Zhong, Chem. Commun., 2015, 51, 8330 DOI: 10.1039/C5CC02096D

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