Issue 46, 2015
From the journal:

Chemical Communications

A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy†

Peilian Liu,a   Jiangsheng Xu,a   Donghang Yan,a   Peisheng Zhang,a   Fang Zeng,*a   Bowen Lia  and  Shuizhu Wu*a  

* Corresponding authors

a College of Materials Science & Engineering, State Key Lab of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, P. R. China
E-mail: shzhwu@scut.edu.cn, mcfzeng@scut.edu.cn
Fax: +86 20 22236363
Tel: +86 20 22236262

Abstract

A DT-diaphorase-activatable theranostic prodrug, which contains camptothecin, a self-immolative linker and a trigger group, has been developed for the detection of DT-diaphorase, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase. This strategy may offer a new approach for the development of enzyme-catalyzed theranostic anticancer therapeutics.

Graphical abstract: A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

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Article information

DOI
https://doi.org/10.1039/C5CC02149A
Article type
Communication
Submitted
13 Mar 2015
Accepted
01 May 2015
First published
04 May 2015

Chem. Commun., 2015,51, 9567-9570

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A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

P. Liu, J. Xu, D. Yan, P. Zhang, F. Zeng, B. Li and S. Wu, Chem. Commun., 2015, 51, 9567 DOI: 10.1039/C5CC02149A

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