Issue 57, 2015

Kinetic resolution of 2,3-epoxy 3-aryl ketones via catalytic asymmetric ring-opening with pyrazole derivatives

Abstract

A highly efficient catalytic kinetic resolution of 2,3-epoxy 3-aryl ketones via asymmetric ring-opening with pyrazole derivatives has been achieved by using a chiral N,N′-dioxide–Sc(III) complex as the catalyst. A wide variety of substrates were readily scoped, and the selectivity factors obtained were excellent (up to >300).

Graphical abstract: Kinetic resolution of 2,3-epoxy 3-aryl ketones via catalytic asymmetric ring-opening with pyrazole derivatives

Supplementary files

Article information

Article type
Communication
Submitted
14 Mar 2015
Accepted
24 Apr 2015
First published
11 May 2015

Chem. Commun., 2015,51, 11374-11377

Author version available

Kinetic resolution of 2,3-epoxy 3-aryl ketones via catalytic asymmetric ring-opening with pyrazole derivatives

T. Huang, L. Lin, X. Hu, J. Zheng, X. Liu and X. Feng, Chem. Commun., 2015, 51, 11374 DOI: 10.1039/C5CC02179K

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