Issue 47, 2015

Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation

Abstract

We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine–hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.

Graphical abstract: Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation

Supplementary files

Article information

Article type
Communication
Submitted
21 Mar 2015
Accepted
07 May 2015
First published
11 May 2015

Chem. Commun., 2015,51, 9662-9665

Author version available

Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation

X. Zhang, P. Sun, L. Huangshan, B. Hu and P. B. Messersmith, Chem. Commun., 2015, 51, 9662 DOI: 10.1039/C5CC02367J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements