Issue 44, 2015
From the journal:

Chemical Communications

Selective endocytic trafficking in live cells with fluorescent naphthoxazoles and their boron complexes†

Gleiston G. Dias,a   Bernardo L. Rodrigues,a   Jarbas M. Resende,a   Hállen D. R. Calado,a   Carlos A. de Simone,b   Valter H. C. Silva,c   Brenno A. D. Neto,d   Marilia O. F. Goulart,e   Fabricia R. Ferreira,e   Assuero S. Meira,f   Claudia Pessoa,fg   José R. Correa*d  and  Eufrânio N. da Silva Júnior*a  

* Corresponding authors

a Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
E-mail: eufranio@ufmg.br

b Institute of Physics, Department of Physics and Informatics, University of São Paulo, São Carlos, SP, Brazil

c University Unit of Exact Sciences and Technology, State University from Goiás, Anápolis, GO, Brazil

d Laboratory of Medicinal & Technological Chemistry, Institute of Chemistry, University of Brasilia, P.O. Box 4478, Brasilia, DF, Brazil
E-mail: correa@unb.br

e Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, AL, Brazil

f Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil

g Fiocruz-CE, Fortaleza, CE, Brazil

Abstract

Fluorescent naphthoxazoles and their boron derivatives have been synthesized and applied as superior and selective probes for endocytic pathway tracking in live cancer cells. The best fluorophores were compared with the commercially available acridine orange (co-staining experiments), showing far better selectivity.

Graphical abstract: Selective endocytic trafficking in live cells with fluorescent naphthoxazoles and their boron complexes

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Article information

DOI
https://doi.org/10.1039/C5CC02383A
Article type
Communication
Submitted
23 Mar 2015
Accepted
24 Apr 2015
First published
27 Apr 2015

Chem. Commun., 2015,51, 9141-9144

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Selective endocytic trafficking in live cells with fluorescent naphthoxazoles and their boron complexes

G. G. Dias, B. L. Rodrigues, J. M. Resende, H. D. R. Calado, C. A. de Simone, V. H. C. Silva, B. A. D. Neto, M. O. F. Goulart, F. R. Ferreira, A. S. Meira, C. Pessoa, J. R. Correa and E. N. da Silva Júnior, Chem. Commun., 2015, 51, 9141 DOI: 10.1039/C5CC02383A

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