Issue 43, 2015
From the journal:

Chemical Communications

Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics†

Weijie Zhang,‡ab   Ryan T. K. Kwok,‡bc   Yilong Chen,bc   Sijie Chen,bc   Engui Zhao,bc   Chris Y. Y. Yu,bc   Jacky W. Y. Lam,bc   Qichang Zheng*a  and  Ben Zhong Tang*bcd  

* Corresponding authors

a Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
E-mail: qc_zheng@mail.hust.edu.cn

b Department of Chemistry, Institute for Advanced Study, Division of Biomedical Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

c HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park, Nanshan, Shenzhen 518057, China

d Guangdong Innovative Research Team, SCUT-HKUST Joint Research Laboratory, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China

Abstract

An isothiocyanate-functionalized tetraphenylethene is synthesized and used as a fluorescent bioprobe for mitochondrion imaging with high specificity and photostability. The covalent conjugation of the bioprobe to mitochondrial proteins endows it with high resistance to microenvironmental changes, enabling it for real-time monitoring of mitophagy.

Graphical abstract: Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics

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Article information

DOI
https://doi.org/10.1039/C5CC02486B
Article type
Communication
Submitted
25 Mar 2015
Accepted
23 Apr 2015
First published
23 Apr 2015

Chem. Commun., 2015,51, 9022-9025

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Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics

W. Zhang, R. T. K. Kwok, Y. Chen, S. Chen, E. Zhao, C. Y. Y. Yu, J. W. Y. Lam, Q. Zheng and B. Z. Tang, Chem. Commun., 2015, 51, 9022 DOI: 10.1039/C5CC02486B

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