Issue 56, 2015
From the journal:

Chemical Communications

Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T2 contrast enhancement in magnetic resonance imaging†

Alexandre D. A. Zottis,ab   Jeovandro M. Beltrame,b   Luciano R. S. Lara,b   Thiago G. Costa,c   Mateus J. Feldhaus,b   Rozangela Curi Pedrosa,d   Fabiana Ourique,d   Carlos E. M. de Campos,e   Eduardo de A. Isoppo,e   Fabio da Silva Mirandaf  and  Bruno Szpoganicz*b  

* Corresponding authors

a Academic Department of Health and Services, Nucleus of Clinical Technology, Instituto Federal de Educação, Ciência e Tecnologia de Santa Catarina, Campus Florianópolis, SC, Brazil
E-mail: adz@ifsc.edu.br
Tel: +55 4832210569

b Chemistry Department, Universidade Federal de Santa Catarina, Trindade Campus, Florianópolis, SC, Brazil
E-mail: bruno.s@ufsc.br
Tel: +55 4837216847 ext. 216

c Laboratório do Ateliê de Conservação e Restauração de Bens Culturais Móveis, Fundação Catarinense de Cultura, Florianópolis, SC, Brazil

d Experimental Biochemistry Laboratory, Biochemistry Department, Universidade Federal de Santa Catarina, Trindade Campus, Florianopolis, SC, Brazil

e Physics Department, Universidade Federal de Santa Catarina, Trindade Campus, Florianópolis, SC, Brazil

f Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil

Abstract

We describe herein a novel type of monodisperse water-soluble magnetite nanoparticle coated with pheomelanin using an environmentally-friendly approach in aqueous medium. The results indicate superparamagnetic behaviour at room temperature and show improved negative contrast in T2-weighted MRI with a transverse relaxivity of 218 mM−1 s−1.

Graphical abstract: Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T2 contrast enhancement in magnetic resonance imaging

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Article information

DOI
https://doi.org/10.1039/C5CC02536B
Article type
Communication
Submitted
27 Mar 2015
Accepted
01 Jun 2015
First published
01 Jun 2015

Chem. Commun., 2015,51, 11194-11197

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Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T2 contrast enhancement in magnetic resonance imaging

A. D. A. Zottis, J. M. Beltrame, L. R. S. Lara, T. G. Costa, M. J. Feldhaus, R. C. Pedrosa, F. Ourique, C. E. M. de Campos, E. D. A. Isoppo, F. da Silva Miranda and B. Szpoganicz, Chem. Commun., 2015, 51, 11194 DOI: 10.1039/C5CC02536B

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