Issue 44, 2015
From the journal:

Chemical Communications

Body temperature sensitive micelles for MRI enhancement†

Xiaolei Zhu,a   Shizhen Chen,a   Qing Luo,a   Chaohui Ye,a   Maili Liua  and  Xin Zhou*a  

* Corresponding authors

a Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center of Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China
E-mail: xinzhou@wipm.ac.cn

Abstract

A novel thermo-sensitive micelle contrast agent and its enhancement of MRI contrast with temperature are reported. The morphology changes sharply near 37 °C, resulting in a significant amplification of the CEST signal. This enables detection of small changes in body temperature.

Graphical abstract: Body temperature sensitive micelles for MRI enhancement

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Article information

DOI
https://doi.org/10.1039/C5CC02587G
Article type
Communication
Submitted
29 Mar 2015
Accepted
02 Apr 2015
First published
02 Apr 2015

Chem. Commun., 2015,51, 9085-9088

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Body temperature sensitive micelles for MRI enhancement

X. Zhu, S. Chen, Q. Luo, C. Ye, M. Liu and X. Zhou, Chem. Commun., 2015, 51, 9085 DOI: 10.1039/C5CC02587G

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