Issue 55, 2015

Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal

Abstract

A simple and selective assay for detecting methylglyoxal (MGO), a metabolite associated with diabetes, was developed by combining a bio-inspired chemical reaction with the anti-aggregation of gold nanoparticles. This assay could detect MGO at as low as 1 μM by the naked eye and 0.05 μM by UV/vis spectrometry, within the clinical range marking oxidative stress in diabetes, and demonstrated high selectivity over other physiologically relevant ketones and aldehydes.

Graphical abstract: Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal

Supplementary files

Article information

Article type
Communication
Submitted
30 Mar 2015
Accepted
02 Jun 2015
First published
15 Jun 2015

Chem. Commun., 2015,51, 11026-11029

Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal

S. Wang, Y. Lin, C. D. Spicer and M. M. Stevens, Chem. Commun., 2015, 51, 11026 DOI: 10.1039/C5CC02590G

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