Water soluble, cyclometalated Pt(II)–Ln(III) conjugates towards novel bimodal imaging agents

Oliver J. Stacey; Angelo J. Amoroso; James A. Platts; Peter N. Horton; Simon J. Coles; David Lloyd; Catrin F. Williams; Anthony J. Hayes; Jay J. Dunsford; Simon J. A. Pope

doi:10.1039/C5CC02623G

Water soluble, cyclometalated Pt(ii)–Ln(iii) conjugates towards novel bimodal imaging agents†

Oliver J. Stacey,^a Angelo J. Amoroso,^a James A. Platts,^a Peter N. Horton,^b Simon J. Coles,

^b David Lloyd,^c Catrin F. Williams,^c Anthony J. Hayes,^c Jay J. Dunsford^d and Simon J. A. Pope*^a

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* Corresponding authors

^a School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, UK
E-mail: popesj@cardiff.ac.uk
Tel: +44 02920 879316

^b UK National Crystallographic Service, Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Highfield, Southampton, UK SO17 1BJ

^c School of Biosciences, Main Building, Cardiff University, Park Place, Cardiff, UK CF10 3AT

^d School of Chemistry, The University of Manchester, Manchester, UK M13 9PL

Abstract

Facile conjugation of a luminescent cyclometalated Pt^II complex with a DO3A-derived Gd^III moiety yields a hybrid species with visible luminescence and enhanced relaxivity.

Chemical Communications

Water soluble, cyclometalated Pt(ii)–Ln(iii) conjugates towards novel bimodal imaging agents†

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Water soluble, cyclometalated Pt(II)–Ln(III) conjugates towards novel bimodal imaging agents

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