Issue 42, 2015

Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation

Abstract

Difluoromethylation of the activated X–H bond (X = N, O and S) and aliphatic thiols, and gem-difluorocyclopropenation of alkynes with difluorocarbene generated in situ from difluoromethylene phosphobetaine (Ph3P+CF2CO2) by decarboxylation occurred smoothly without the presence of any base or other additives.

Graphical abstract: Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr 2015
Accepted
20 Apr 2015
First published
20 Apr 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 8805-8808

Author version available

Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation

X. Deng, J. Lin, J. Zheng and J. Xiao, Chem. Commun., 2015, 51, 8805 DOI: 10.1039/C5CC02736E

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