Issue 53, 2015
From the journal:

Chemical Communications

A novel azopyridine-based Ru(ii) complex with GSH-responsive DNA photobinding ability†

Qian-Xiong Zhou,*a   Yue Zheng,ab   Tian-Ji Wang,ab   Yong-Jie Chen,ab   Ke Li,ab   Yang-Yang Zhang,ab   Chao Li,a   Yuan-Jun Houa  and  Xue-Song Wang*a  

* Corresponding authors

a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: xswang@mail.ipc.ac.cn, zhouqianxiong@mail.ipc.ac.cn
Fax: +86-10-62564049
Tel: +86-10-82543592

b Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

A novel azopyridine-based Ru(II) complex [Ru(bpy)2(L1)2]2+ (bpy = 2,2′-bipyridine, L1 = 4,4′-azopyridine) was designed and synthesized as a potential glutathione (GSH)-responsive photoactivated chemotherapy (PACT) agent, the DNA covalent binding capability of which can only be activated after GSH reduction and visible light irradiation.

Graphical abstract: A novel azopyridine-based Ru(ii) complex with GSH-responsive DNA photobinding ability

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Article information

DOI
https://doi.org/10.1039/C5CC03291A
Article type
Communication
Submitted
21 Apr 2015
Accepted
21 May 2015
First published
21 May 2015

Chem. Commun., 2015,51, 10684-10686

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A novel azopyridine-based Ru(II) complex with GSH-responsive DNA photobinding ability

Q. Zhou, Y. Zheng, T. Wang, Y. Chen, K. Li, Y. Zhang, C. Li, Y. Hou and X. Wang, Chem. Commun., 2015, 51, 10684 DOI: 10.1039/C5CC03291A

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