Issue 56, 2015

Pd-catalyzed cross-coupling of terminal alkynes with ene-yne-ketones: access to conjugated enynes via metal carbene migratory insertion

Abstract

A novel strategy for alkyne–alkyne cross-coupling has been developed under the palladium catalysis. In this reaction, ene-yne-ketones are employed as carbene precursors, which couple with terminal alkynes through the metal carbene migratory insertion process. Furan-substituted enynes are obtained in good yields and in a stereoselective manner.

Graphical abstract: Pd-catalyzed cross-coupling of terminal alkynes with ene-yne-ketones: access to conjugated enynes via metal carbene migratory insertion

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2015
Accepted
02 Jun 2015
First published
02 Jun 2015

Chem. Commun., 2015,51, 11233-11235

Author version available

Pd-catalyzed cross-coupling of terminal alkynes with ene-yne-ketones: access to conjugated enynes via metal carbene migratory insertion

Y. Xia, Z. Liu, R. Ge, Q. Xiao, Y. Zhang and J. Wang, Chem. Commun., 2015, 51, 11233 DOI: 10.1039/C5CC03559G

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