SCHEDULED MAINTENANCE
An automated, continuous flow droplet screening system is presented, enabling real-time simultaneous solvent and continuous variable optimization. An optimal design of experiments strategy is applied to the alkylation of 1,2-diaminocyclohexane in 16 μL droplets, with scale-up demonstrated. Analysis of segmented flow results suggests correlation of yield with solvent hydrogen bond basicity.
B. J. Reizman and K. F. Jensen, Chem. Commun., 2015, 51, 13290 DOI: 10.1039/C5CC03651H
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