Issue 56, 2015

Organocatalytic enantioselective formal arylation of azlactones using quinones as the aromatic partner

Abstract

A new method for the catalytic enantioselective formal arylation of azlactones using quinones as the aromatic partner was developed for the first time. Under mild conditions, the domino Michael/aromatization/cyclization reaction worked well to afford the corresponding products in moderate to high yields with excellent enantioselectivities, some of which have promising cytotoxicity against cancer cells and antibacterial activities.

Graphical abstract: Organocatalytic enantioselective formal arylation of azlactones using quinones as the aromatic partner

Supplementary files

Article information

Article type
Communication
Submitted
03 May 2015
Accepted
02 Jun 2015
First published
02 Jun 2015

Chem. Commun., 2015,51, 11280-11282

Organocatalytic enantioselective formal arylation of azlactones using quinones as the aromatic partner

G. Li, W. Sun, J. Li, F. Jia, L. Hong and R. Wang, Chem. Commun., 2015, 51, 11280 DOI: 10.1039/C5CC03677A

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