Issue 60, 2015
From the journal:

Chemical Communications

A Golgi-localized two-photon probe for imaging zinc ions†

Hardev Singh,‡a   Hyo Won Lee,‡a   Cheol Ho Heo,a   Ji Won Byun,a   Avik Ranjan Sarkara  and  Hwan Myung Kim*a  

* Corresponding authors

a Department of Chemistry and Department of Energy Systems Research, Ajou University, Suwon 443-749, Korea
E-mail: kimhm@ajou.ac.kr
Fax: +82-31-219-1615

Abstract

We report a two-photon fluorescent probe which shows a strong two photon excited fluorescence enhancement in response to Zn2+, easy loading into the cells, Golgi-localizing ability, low cytotoxicity, and high photostability. Two-photon microscopy imaging revealed that this probe allows for real-time monitoring of the changes in Golgi Zn2+ as well as their 3D distributions in live cells and tissues.

Graphical abstract: A Golgi-localized two-photon probe for imaging zinc ions

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Article information

DOI
https://doi.org/10.1039/C5CC03884G
Article type
Communication
Submitted
11 May 2015
Accepted
18 Jun 2015
First published
18 Jun 2015

Chem. Commun., 2015,51, 12099-12102

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A Golgi-localized two-photon probe for imaging zinc ions

H. Singh, H. W. Lee, C. H. Heo, J. W. Byun, A. R. Sarkar and H. M. Kim, Chem. Commun., 2015, 51, 12099 DOI: 10.1039/C5CC03884G

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