Issue 67, 2015
From the journal:

Chemical Communications

A contamination-insensitive probe for imaging specific biomolecules by secondary ion mass spectrometry†

Selda Kabatas,‡a   Ingrid C. Vreja,‡bc   Sinem K. Saka,b   Carmen Höschen,d   Katharina Kröhnert,b   Felipe Opazo,b   Silvio O. Rizzoli*be  and  Ulf Diederichsen*ae  

* Corresponding authors

a Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstr. 2, D-37077 Göttingen, Germany
E-mail: udieder@gwdg.de

b Department of Neuro- and Sensory Physiology, University Medical Centre Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany
E-mail: srizzol@gwdg.de

c International Max Planck Research School Molecular Biology, Göttingen, Germany

d Department of Ecology and Ecosystem Management, Centre of Life and Food Sciences Weihenstephan, Technische Universität München, Emil-Ramann-Straße 2, D-85354 Freising, Germany

e Centre for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany

Abstract

Imaging techniques should differentiate between specific signals, from the biomolecules of interest, and non-specific signals, from the background. We present a probe containing 15N and 14N isotopes in approximately equal proportion, for secondary ion mass spectrometry imaging. This probe designed for a precise biomolecule analysis is insensitive to background signals.

Graphical abstract: A contamination-insensitive probe for imaging specific biomolecules by secondary ion mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C5CC03895B
Article type
Communication
Submitted
11 May 2015
Accepted
07 Jul 2015
First published
07 Jul 2015

Chem. Commun., 2015,51, 13221-13224

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A contamination-insensitive probe for imaging specific biomolecules by secondary ion mass spectrometry

S. Kabatas, I. C. Vreja, S. K. Saka, C. Höschen, K. Kröhnert, F. Opazo, S. O. Rizzoli and U. Diederichsen, Chem. Commun., 2015, 51, 13221 DOI: 10.1039/C5CC03895B

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