Issue 54, 2015

Emerging approaches for the synthesis of triazoles: beyond metal-catalyzed and strain-promoted azide–alkyne cycloaddition

Abstract

Metal-free 1,3-dipolar cycloaddition reactions have proven to be a powerful tool for the assembly of key heterocycles, in particular diversely functionalized 1,2,3-triazoles. A number of metal-free (3+2)-cycloaddition approaches have been developed up to date with the aim to circumvent the use of metal catalysts allowing these reactions to take place in biological systems without perturbation of the naturally occurring processes. This feature article specifically provides an overview of emerging metal-free synthetic routes, and their mechanistic features, in the formation of functionalized 1,2,3-triazoles.

Graphical abstract: Emerging approaches for the synthesis of triazoles: beyond metal-catalyzed and strain-promoted azide–alkyne cycloaddition

Associated articles

Article information

Article type
Feature Article
Submitted
18 May 2015
Accepted
01 Jun 2015
First published
10 Jun 2015

Chem. Commun., 2015,51, 10784-10796

Author version available

Emerging approaches for the synthesis of triazoles: beyond metal-catalyzed and strain-promoted azide–alkyne cycloaddition

C. G. S. Lima, A. Ali, S. S. van Berkel, B. Westermann and M. W. Paixão, Chem. Commun., 2015, 51, 10784 DOI: 10.1039/C5CC04114G

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