Diverse display of non-covalent interacting elements using pyrimidine-embedded polyheterocycles

Abstract

A series of pyrimidine-embedded polyheterocycles was synthesized using a pDOS strategy in a facile manner. The resulting poly-heterocyclic core skeletons containing a unique aza-tricyclic framework allowed for diverse display of non-covalent interacting elements, which probably serve as essentials for perturbing specific non-covalent interactions between various biopolymers.