Issue 62, 2015
From the journal:

Chemical Communications

A target-induced three-way G-quadruplex junction for 17β-estradiol monitoring with a naked-eye readout†

Junhua Chen,a   Junlin Wen,a   Guiqin Yanga  and  Shungui Zhou*a  

* Corresponding authors

a Guangdong Key Laboratory of Agricultural Environment Pollution Integrated Control, Guangdong Institute of Eco-Environmental and Soil Sciences, Guangzhou 510650, China
E-mail: sgzhou@soil.gd.cn

Abstract

A label-free and enzyme-free three-way G-quadruplex junction sensing system for the amplified detection of 17β-estradiol has been constructed by the ingenious coupling of split G-quadruplex DNAzyme with toehold-mediated strand displacement. The biosensor is ultrasensitive, enabling the visual detection of 17β-estradiol concentrations as low as 1 fM without instrumentation.

Graphical abstract: A target-induced three-way G-quadruplex junction for 17β-estradiol monitoring with a naked-eye readout

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Article information

DOI
https://doi.org/10.1039/C5CC04347F
Article type
Communication
Submitted
27 May 2015
Accepted
23 Jun 2015
First published
23 Jun 2015

Chem. Commun., 2015,51, 12373-12376

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A target-induced three-way G-quadruplex junction for 17β-estradiol monitoring with a naked-eye readout

J. Chen, J. Wen, G. Yang and S. Zhou, Chem. Commun., 2015, 51, 12373 DOI: 10.1039/C5CC04347F

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