Issue 60, 2015

Gene delivery polymer structure–function relationships elucidated via principal component analysis

Abstract

Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability).

Graphical abstract: Gene delivery polymer structure–function relationships elucidated via principal component analysis

Supplementary files

Article information

Article type
Communication
Submitted
29 May 2015
Accepted
22 Jun 2015
First published
22 Jun 2015

Chem. Commun., 2015,51, 12134-12137

Author version available

Gene delivery polymer structure–function relationships elucidated via principal component analysis

C. J. Bishop, B. Abubaker-Sharif, T. Guiriba, S. Y. Tzeng and J. J. Green, Chem. Commun., 2015, 51, 12134 DOI: 10.1039/C5CC04417K

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