Issue 70, 2015

A novel visible light mediated radical cyclization of enol lactones: a concise method for fluorinated polycyclic lactone scaffolds

Abstract

A novel visible light mediated radical cyclization of enol lactones with difluoroacyl arenes is presented. The reaction experienced a tandem radical cyclization and tolerated a wide range of substrates, resulting in fluorinated γ-butyrolactones in good chemical yield and with excellent diastereoselectivity.

Graphical abstract: A novel visible light mediated radical cyclization of enol lactones: a concise method for fluorinated polycyclic lactone scaffolds

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2015
Accepted
16 Jul 2015
First published
16 Jul 2015

Chem. Commun., 2015,51, 13508-13510

Author version available

A novel visible light mediated radical cyclization of enol lactones: a concise method for fluorinated polycyclic lactone scaffolds

C. Qu, P. Xu, W. Ma, Y. Cheng and C. Zhu, Chem. Commun., 2015, 51, 13508 DOI: 10.1039/C5CC04881H

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