Issue 77, 2015
From the journal:

Chemical Communications

A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3†

Shi-Ying Li,‡a   Li-Han Liu,‡a   Hong Cheng,a   Bin Li,a   Wen-Xiu Qiua  and  Xian-Zheng Zhang*a  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: xz-zhang@whu.edu.cn
Fax: +86 27 6875 4509
Tel: +86 27 6875 5993

Abstract

A novel dual-FRET-based fluorescence probe was designed and synthesized for the sequential detection of MMP-2 and caspase-3. This probe can successfully monitor Dox- and UV-induced cell apoptosis signals in real time and in situ, which demonstrated its great potential for apoptosis-related drug screening and dynamic apoptosis imaging.

Graphical abstract: A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3

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Article information

DOI
https://doi.org/10.1039/C5CC04962H
Article type
Communication
Submitted
16 Jun 2015
Accepted
28 Jul 2015
First published
05 Aug 2015

Chem. Commun., 2015,51, 14520-14523

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A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3

S. Li, L. Liu, H. Cheng, B. Li, W. Qiu and X. Zhang, Chem. Commun., 2015, 51, 14520 DOI: 10.1039/C5CC04962H

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