DNA-caged gold nanoparticles for controlled release of doxorubicin triggered by a DNA enzyme and pH

Abstract

DNA polyhedron-caged gold nanoparticles (AuNP) were self-assembled using four-point-star DNAs, with three strands hybridizing to each other and the fourth strand attaching to the AuNPs. The DNA-caged AuNPs can work as nanocarriers for doxorubicin, and controlled release behaviour can be triggered by both a DNA enzyme and by the pH value.