Issue 92, 2015
From the journal:

Chemical Communications

Chemical labeling of intracellular proteins via affinity conjugation and strain-promoted cycloadditions in live cells†

Xi Chen,ab   Fu Liab  and  Yao-Wen Wu*ab  

* Corresponding authors

a Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Str. 15, 44227 Dortmund, Germany
E-mail: yaowen.wu@mpi-dortmund.mpg.de

b Max-Planck Institute for Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany

Abstract

A versatile chemical labeling approach was developed, where intracellular proteins were first incorporated with a bioorthogonal group via affinity conjugation, and subsequently labeled via strain-promoted cycloaddition reactions in live cells.

Graphical abstract: Chemical labeling of intracellular proteins via affinity conjugation and strain-promoted cycloadditions in live cells

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Article information

DOI
https://doi.org/10.1039/C5CC05208D
Article type
Communication
Submitted
24 Jun 2015
Accepted
18 Sep 2015
First published
18 Sep 2015

Chem. Commun., 2015,51, 16537-16540

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Chemical labeling of intracellular proteins via affinity conjugation and strain-promoted cycloadditions in live cells

X. Chen, F. Li and Y. Wu, Chem. Commun., 2015, 51, 16537 DOI: 10.1039/C5CC05208D

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