Enantio-differentiation of molecules with diverse functionalities using a single probe

Abstract

This study reports (1S,2S)-N,N′-dihydroxy-N,N′-bis(diphenylacetyl)-1,2-cyclohexanediamine, a C₂ symmetric chiral hydroxamic acid ((S)-CBHA-DPA), as a unique probe for discrimination of molecules with diverse functionalities. The proposed CSA is also utilized for the accurate measurement of enantiomeric excess.