Issue 76, 2015
From the journal:

Chemical Communications

Evaluation of DNA methyltransferase activity and inhibition via chiroplasmonic assemblies of gold nanoparticles†

Yuanjian Liu,a   Min Wei,b   Linqun Zhang,a   Wei Wei,*a   Yuanjian Zhanga  and  Songqin Liua  

* Corresponding authors

a Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China
E-mail: wei_wei98@163.com

b College of Food Science and Technology, Henan University of Technology, Zhengzhou, China

Abstract

Circular dichroism spectroscopy has been explored for detection of methyltransferase activity and inhibition based on DNA-induced chiroplasmonic assemblies of gold nanoparticles and endonuclease HpaII. Good accuracy, precision and sensitivity are obtained in complex matrices such as human serum samples, which is significant for clinical diagnosis and drug development.

Graphical abstract: Evaluation of DNA methyltransferase activity and inhibition via chiroplasmonic assemblies of gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C5CC05375G
Article type
Communication
Submitted
05 Jul 2015
Accepted
31 Jul 2015
First published
31 Jul 2015

Chem. Commun., 2015,51, 14350-14353

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Evaluation of DNA methyltransferase activity and inhibition via chiroplasmonic assemblies of gold nanoparticles

Y. Liu, M. Wei, L. Zhang, W. Wei, Y. Zhang and S. Liu, Chem. Commun., 2015, 51, 14350 DOI: 10.1039/C5CC05375G

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