Issue 70, 2015
From the journal:

Chemical Communications

Chemical generation and modification of peptides containing multiple dehydroalanines†

Philip M. Morrison,a   Patrick J. Foley,a   Stuart L. Warrinera  and  Michael E. Webb*a  

* Corresponding authors

a School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK
E-mail: m.e.webb@leeds.ac.uk

Abstract

Chemical formation of dehydroalanine has been widely used for the post-translational modification of proteins and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used to cleanly carry out this transformation.

Graphical abstract: Chemical generation and modification of peptides containing multiple dehydroalanines

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Article information

DOI
https://doi.org/10.1039/C5CC05469A
Article type
Communication
Submitted
02 Jul 2015
Accepted
22 Jul 2015
First published
23 Jul 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 13470-13473

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Chemical generation and modification of peptides containing multiple dehydroalanines

P. M. Morrison, P. J. Foley, S. L. Warriner and M. E. Webb, Chem. Commun., 2015, 51, 13470 DOI: 10.1039/C5CC05469A

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