Selective remote C–H sulfonylation of aminoquinolines with arylsulfonyl chlorides via copper catalysis

Abstract

Copper-catalysed direct C–H bond sulfonylation of aminoquinolines using commercially available and inexpensive arylsulfonyl chlorides as the sulfonylation reagents is described. The reactions took place exclusively at the C5–H position of the quinoline rings and tolerated a wide spectrum of functional groups. Moreover, synthetic transformations of the sulfonylated products led to useful compounds.