Issue 4, 2016

Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools

Abstract

Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

Graphical abstract: Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools

Supplementary files

Article information

Article type
Communication
Submitted
23 Jul 2015
Accepted
09 Nov 2015
First published
09 Nov 2015

Chem. Commun., 2016,52, 784-787

Author version available

Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools

V. Abbate, O. Reelfs, X. Kong, C. Pourzand and R. C. Hider, Chem. Commun., 2016, 52, 784 DOI: 10.1039/C5CC06170A

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