Issue 90, 2015

A new enzyme-free quadratic SERS signal amplification approach for circulating microRNA detection in human serum

Abstract

In this communication, we proposed a new enzyme-free quadratic SERS signal amplification approach for the ultrasensitive detection of circulating miRNA in human serum. Combined with miRNA-triggered hybridization chain reaction and Ag+-mediated cascade amplification, a limit of miRNA detection as low as 0.3 fM could be achieved. More importantly, our method is suitable for the direct detection of circulating miRNAs in human serum collected from patients with different stages of chronic lymphocytic leukemia (CLL).

Graphical abstract: A new enzyme-free quadratic SERS signal amplification approach for circulating microRNA detection in human serum

Supplementary files

Article information

Article type
Communication
Submitted
05 Aug 2015
Accepted
09 Sep 2015
First published
10 Sep 2015

Chem. Commun., 2015,51, 16271-16274

Author version available

A new enzyme-free quadratic SERS signal amplification approach for circulating microRNA detection in human serum

J. Zheng, D. Ma, M. Shi, J. Bai, Y. Li, J. Yang and R. Yang, Chem. Commun., 2015, 51, 16271 DOI: 10.1039/C5CC06549F

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