Issue 4, 2016
From the journal:

Chemical Communications

Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides†

Andreas Prestela  and  Heiko M. Möller*ab  

* Corresponding authors

a Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, 78464 Konstanz, Germany

b Institute of Chemistry/Analytical Chemistry, University of Potsdam, 14476 Potsdam, Germany
E-mail: heiko.moeller@uni-potsdam.de

Abstract

The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control.

Graphical abstract: Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides

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Article information

DOI
https://doi.org/10.1039/C5CC06848G
Article type
Communication
Submitted
14 Aug 2015
Accepted
30 Oct 2015
First published
04 Nov 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 701-704

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Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides

A. Prestel and H. M. Möller, Chem. Commun., 2016, 52, 701 DOI: 10.1039/C5CC06848G

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