Issue 7, 2016

Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing

Abstract

A catalytic self-assembled DNA dendritic complex was herein reported and used for siRNA-based gene silencing. This kind of one-pot DNA dendrimer can be conveniently prepared as needed, and it was demonstrated to have better silencing efficiency and lower cytotoxicity than commercial cationic lipid transfection agents.

Graphical abstract: Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing

Supplementary files

Article information

Article type
Communication
Submitted
18 Aug 2015
Accepted
17 Nov 2015
First published
18 Nov 2015

Chem. Commun., 2016,52, 1413-1415

Author version available

Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing

Y. Lv, R. Peng, Y. Zhou, X. Zhang and W. Tan, Chem. Commun., 2016, 52, 1413 DOI: 10.1039/C5CC06937H

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